The macular pigment (PM) could protect against age-related macular degeneration. In a study involving 8 people, attempts were made to determine the magnitude of changes in macular pigment density after oral supplementation with lutein. 10 mg of lutein was supplied daily for 12 weeks and the plasma lutein concentration was quantified at 4 week intervals.
At four weeks, the average level of lutein in the blood had increased from 0.18 to 0.90 µM. This level was maintained during the supplementation period and decreased to 0.28 µM at 4 weeks after completion. On the other hand, the PM density showed a linear average increase in the 4-week intervals between 5.3% (p <0.001) and 4.1% (p = 0.022), which concluded that the supplementation with lutein the PM density significantly increased.
Reference: Invest Ophthalmol Vis Sci. 2000; 41: 3322-3326.
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