I would like information about the non-acidic vitamins C and the sustained-release vitamin C ascorbic acid, which is better absorbed, which remains in the body longer and which participates and is better integrated in cellular metabolism.
R) To answer your question it is necessary to analyze all forms of vitamin C available in supplement form.
Ascorbic acid is the form of vitamin C that is found naturally in food. It has good bioavailability, but some people find it too acidic in the gut and cannot tolerate high doses.
Mineral ascorbates such as calcium magnesium ascorbate are often referred to as “buffered” vitamin C. Many people consider them to be milder forms of vitamin C that are better tolerated by the intestines and stomach. However, it is important to consider the accompanying mineral dosage (calcium, magnesium, etc.) when taking higher levels. Clinical trials have shown that calcium ascorbate was better absorbed and therefore was present at higher plasma levels than ascorbic acid.
Ester-C® is a proprietary form of vitamin C (primarily calcium ascorbate) that has been shown to be well absorbed and tolerated in the intestine like other mineral ascorbates. In their literature, the manufacturers claim that metabolites, especially threonate, increase the bioavailability of vitamin C in this product, and they indicate that they have conducted a human study demonstrating increased bioavailability of vitamin C.
Extended-release vitamin C is often the preferred option, as vitamin C has better bioavailability when taken in smaller doses throughout the day. A time-release formula aims to solve this problem without taking multiple tablets, releasing vitamin C slowly throughout the day. Additionally, studies have shown that ascorbic acid, combined with citrus bioflavonoids, is more bioavailable than the synthetic form of ascorbic acid alone. Bioflavonoids increase the bioavailability of Vitamin C by 35%. The addition of Rosehip in the product further increases its bioavailability.